Brain Hexokinase

Kinetic studies of the brain hexokinase reaction.

The mechanism of the hexokinase reaction has been the subject of numerous investigations in recent years (l-5). ijgren and Engstrijm reported the incorporation of Pa from labeled adenosine triphosphate (ATP) into the phosphoserine moiety of hexokinase in the absence of substrate glucose and concluded that an enzyme-phosphate intermediate participated in the reaction (2). Gamble and Najjar, howe...

Inhibitors and activators of brain hexokinase.

Studies on hexokinase. 1. The hexokinase activity of rat-brain extracts.

Mitochondrial hexokinase from small-intestinal mucosa and brain.

1. The submitochondrial localization of hexokinase activity in preparations of mitochondria from the small intestine of the guinea pig was studied by conventional methods. 2. Hexokinase activity in this tissue was predominantly associated with the outer mitochondrial membrane. 3. The inactivation of mitochondrial enzymes by trypsin in iso-osmotic and hypo-osmotic conditions was also used to det...

The hexose specificity of hexokinase in brain from various species.

the ketokinases from different sources differ so widely (liver <0-5 mm and rabbit muscle 0-2M; Hers, 1955). The constant calculated for the locustmuscle enzyme, 5-5 mm, is of the same order as that found for hexokinase from yeast, 1-7 mm, by Slein et al. (1950). We consider that locust muscle contains a single, non-specific hexokinase and that the enzyme is similar to that found in yeast and in...